Khảo sát và đánh giá hiệu quả theo dõi nồng độ vancomycin trong trị liệu tại Bệnh viện Đại học Y Dược thành phố Hồ Chí Minh

Lượt tải về:  

1Trần Ngọc Phương Minh, 1,2*Đặng Nguyễn Đoan Trang

 1 Khoa Dược, Bệnh viện Đại học Y Dược TP. Hồ Chí Minh

2 Khoa Dược, Đại học Y Dược TP. Hồ Chí Minh

*Tác giả liên hệ: trang.dnd@umc.edu.vn

SUMMARY

            Introduction: Therapeutic monitoring of vancomycin levels was associated with improving treatment outcomes and preventing nephrotoxicity and antibiotic resistance. Objectives: The study was designed to investigate the current use of vancomycin, the appropriateness of vancomycin use and vancomycin TDM at University Medical Center Hochiminh City (UMC HCMC). Methods: A descriptive cross-sectional study was performed on 200 patients receiving intravenous vancomycin from January 2017 to May 2017 at UMC HCMC. Exclusion criteria included treatment duration of less than 3 days, patients younger than 18 years old, patients with no diagnosis of infection or with unstable pharmacokinetics (pregnancy, hemodialysis, extreme extracellular fluid loss including burns, vomiting or severe diarrhea, cystic fibrosis, edema or ascites). The data collected was analyzed using SPSS 22.0 software. Results: The prevalence of vancomycin levels monitoring was 43.5 %, of which approximately 41.1 % followed the dosing protocol. 54.1% of vancomycin trough levels were within a range of 10-20 mcg/mL. The prevalence of patients with trough levels of 10-20 mcg/mL was 26 % and 17.5 % reached targeted levels. Compliance to weekly vancomycin TDM and weekly renal function follow-up was observed in 64.4 % and 96.6 % of cases, respectively. Nephrotoxicity was reported in 5.5 % of the study population. Conclusion: The study presented a low rate of vancomycin monitoring, vancomycin dose adjustment and weekly follow-up. There is a need to develop a better solution to optimize treatment outcomes and reduce nephrotoxicity.

Từ khóa: theo dõi nồng độ thuốc trong trị liệu, khoảng trị liệu, nồng độ mục tiêu, vancomycin.

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